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Projects

TRANSCAN VI-Quant-ALL: Automated, absolute quantification of minimal residual disease in patients with acute lymphocytic leukemia

Projektbild

Project description

The aims of Quant-ALL are: (1) Establishment of an amplicon based IG/TR NGS approach using single DNA copy barcoding and droplet microfluidics for IG/TR based MRD quantification in ALL. (2) Optimization of existing bioinformatics tools used for IG/TR NGS to quantify index IG/TR sequences. (3) Transfer of this technology to a pre-existing centrifugal microfluidic platform for full automation and standardization. (4) Validation of technology for childhood and adult ALL using biobanked follow-up samples that are MRD quantified with standard technologies in a reference laboratory.

Start/End of project

01.06.2019 until 31.05.2022

Project manager

Dr. Tobias Hutzenlaub (Prof. Dr. Roland Zengerle)

Contact person

Dr. Tobias Hutzenlaub
Phone:0761 203-73269

Partners

Universitätsklinikum Schleswig-Holstein, Kiel, Deutschland / University Hospital Schleswig-Holstein, Kiel, Germany Fondazione Tettamanti ONLUS, Italien / Fondazione Tettamanti ONLUS, Italy ASST-PG23, Bergamo, Italien / ASST-PG23, Bergamo, Italy CERTH, Griechenland / CERTH, Greece

Funding

BMBF

Keywords

Lab-on-a-Chip, lab-on-a-chip
Benutzerspezifische Werkzeuge